“IN THEORY, YOU CAN GO AFTER ALMOST ANYTHING. POISONS, PATHOGENS, VIRUSES, BACTERIA…”
A British engineer has found a way to filter unwanted cells from blood using magnets — and his tool could be used in clinical trials as soon as next year.
Thanks to existing research, biochemical scientist George Frodsham knew it was possible to force magnetic nanoparticles to bind to specific cells in the body. But while other researchers did so primarily to make those cells show up in images, he wondered whether the same technique might allow doctors to remove unwanted cells from the blood.
“When someone has a tumour you cut it out,” he told The Telegraph. “Blood cancer is a tumour in the blood, so why not just take it out in the same way?”
To that end, he created MediSieve, a treatment technology that works similarly to dialysis, by removing a patient’s blood and infusing it with magnetic nanoparticlesdesigned to bind to a specific disease. It then uses magnets to draw out and trap those cells before pumping the filtered blood back into the patient.
The idea is that doctors could run a person’s blood through the machine several times until their levels of the disease are low enough to be wiped out by drugs or even the patient’s own immune system.
Frodsham’s team is currently awaiting approval from the United Kingdom’s Medicines and Healthcare products Regulatory Agency to trial the system on patients infected with the malaria parasite, which is naturally magnetic thanks to its consumption of its own iron-based waste product.
That human trial could kick off as soon as 2020, and if all goes well, a second trial testing MediSieve on sepsis-causing bacteriacould follow in 2021.
“In theory, you can go after almost anything,” Frodsham told The Telegraph. “Poisons, pathogens, viruses, bacteria, anything that we can specifically bind to we can remove. So it’s a very powerful potential tool.”
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